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points by deskamess 1 day ago | 0 comments

For those who may have tried other variants... is there a big difference between Ozempic/Wegovy/Mounjaro? My doctor prescribed WeGovy but my insurance does not cover it - my spouses does. However Mounjaro is covered by both insurances. Is it worth (effectiveness) switching to Mounjaro? I heard it is a 'double agonist' - what exactly does that mean?

I am also reading up on things called triple agonist but its not readily available in Canada. Web sites with a lot of discussion about peptides and titrating which seems a little difficult.

[–] toomanyrichies 1 day ago

I've lost 28 lbs on Mounjaro in about 3-4 months. One injection per week, self-administered, completely painless. No more 6-8pm food cravings. That's on top of the money I save vs. eating out all the time (spending maybe $500-600 less per month than I used to, vs. $800 every 6 months for the medicine itself, without insurance). YMMV if you cook at home a lot, but I consider it one of the best lifestyle decisions I've made in recent memory.

[–] illegalbyte2 1 day ago

Mounjaro is the more effective option of the 3 anyway so if that’s your goal and it’s covered, go with it. Double agonist means it targets two hormone pathways. I was on mounjaro for 6-8 months and no regrets. I was offered the 3 alternatives, and was explained the efficacy of mounjaro so went with that one. No reported downsides other than sulphur burps but I think that’s universal.

[–] happyPersonR 1 day ago

It works quite well. I have a ton of friends that have lost a ton on it. But the main benefit is the health side. My blood sugar with not just the the weight loss is back to normal.

Folks really only discontinue because of cost … which is because our health system is a disaster

[–] seanmcdirmid 1 day ago

Wegovy has a pill, super convenient if you don’t want to prick yourself with an auto injector every week, but requires a 30 minute fast every morning and might be less effective. Also, the pills travel better since they don’t require refrigeration. I pay out of pocket with an HsA around $330/month on Amazon.

[–] JKCalhoun 19 hours ago

I'll add that Zepbound is the same as Mounjaro, I believe (both add tirzepatide to the basic Ozempic/Wegovy drug).

[–] nly 1 day ago

I started wegovy 3 weeks ago (1.5mg oral dose) and so far have felt absolutely nothing, good or bad.

I'm assuming this is normal and something will happen when I up the dose.

[–] seanmcdirmid 1 day ago

Ya, you are still ramping and the smaller doses are to see if there will be problems before you hit 30mg. You should notice something when you hit 10mg though.

[–] gruturo 23 hours ago

30mg is an extremely high dosage, far beyond the maximum Semaglutide (Wegovy) trials (which initially topped out at 2.4 and years later validated a new max of 7.2) and likely to land you in a hospital.

Even 10mg is very, very high, beyond the trials maximums (though preliminary small escalation trials tested that, even reaching 16mg, I guess the participants really didn’t enjoy that) and would have serious side effects if not result in a hospital visit as well.

Please be a lot more careful dispensing advice on a public forum on matters where people could get hurt.

[–] iand 22 hours ago

Oral Wegovy is dispensed in higher doses than injection presumably because uptake via the gut is lower.

[–] JKCalhoun 19 hours ago

Yeah, came here to say you can't compare dosages across drugs—they are in some cases an order of magnitude different.

[–] seanmcdirmid 13 hours ago

I misremembered the dosage, it’s 25 mg, not 30 mg. It’s pretty standard for oral, since absorption is different from injection.

[–] MisterMunchkin 23 hours ago

Ozempic and wegovy are a much more primitive drug and gave me worse side effects. Mounjaro is significantly better and proven to be more effective. Ozempic is cheaper though.

[–] randycupertino 1 day ago

I had a lot more success and less side effects on Zepbound vs Wegovy. I pay out of pocket for Zepbound through Lily Direct and even with a coupon it's $500 a month. Without the coupon it would be $2k a month! It's worth it for me, though even though it hurts my wallet.

The triple agonists like Retatrutide should be available in ~6 months assuming all goes well with their trials. Unless you are Trump who got special permission to get it before everyone else! https://www.statnews.com/2026/06/23/eli-lilly-unusual-weight...

[–] taurath 1 day ago

Whoa, thru amazon pharmacy you can get it for 300 after the $200 Lily coupon FYI.

[–] JKCalhoun 19 hours ago

Zepbond is $300/month from the pharmacy (CVS) as well… with the Lily coupon.

But as the dosage climbs, so does the price. I started at the $300/month dosage and am up to the $350/month dosage.

(Hopefully I get to my target weight at this dosage—it's very possible.)

[–] randycupertino 1 day ago

!! I will check that out. I used to use Amazon pharmacy and it was $700 a month so I switched to Lily Direct which was $200 cheaper. Thanks for the tip.