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points by nly 1 day ago | 0 comments

I started wegovy 3 weeks ago (1.5mg oral dose) and so far have felt absolutely nothing, good or bad.

I'm assuming this is normal and something will happen when I up the dose.

Ya, you are still ramping and the smaller doses are to see if there will be problems before you hit 30mg. You should notice something when you hit 10mg though.

[–] gruturo 23 hours ago

30mg is an extremely high dosage, far beyond the maximum Semaglutide (Wegovy) trials (which initially topped out at 2.4 and years later validated a new max of 7.2) and likely to land you in a hospital.

Even 10mg is very, very high, beyond the trials maximums (though preliminary small escalation trials tested that, even reaching 16mg, I guess the participants really didn’t enjoy that) and would have serious side effects if not result in a hospital visit as well.

Please be a lot more careful dispensing advice on a public forum on matters where people could get hurt.

[–] iand 22 hours ago

Oral Wegovy is dispensed in higher doses than injection presumably because uptake via the gut is lower.

[–] JKCalhoun 19 hours ago

Yeah, came here to say you can't compare dosages across drugs—they are in some cases an order of magnitude different.

[–] seanmcdirmid 13 hours ago

I misremembered the dosage, it’s 25 mg, not 30 mg. It’s pretty standard for oral, since absorption is different from injection.