Previous research had identified changes to gene expression in domesticated Siberian silver foxes that would affect the hypothalamus[1], but good to have further confirmation that the changes in gene expression resulted in structural changes too. Would be curious to know if anyone has done an analysis of the difference between wolves and dogs for comparison (or humans and chimpanzees for thar matter).

[1] https://pubmed.ncbi.nlm.nih.gov/31605445/

Has this already been tried with humans?